Researchers at North-West University are studying Lessertia frutescens, commonly known as the cancer bush. Laboratory results previously revealed promising anti-cancer activity against several cancer types, including drug-resistant small cell lung cancer and colorectal cancer.

They are developing a complementary medicine product that may be available in pharmacies by next year. The initiative forms part of ongoing work at the university, where scientists are exploring the medicinal potential of the indigenous plant in the search for new cancer treatment options.

Lessertia frutescens is a much-respected, long-used medicinal plant and a garden plant, cultivated for many years for its form, colour, and luminous flowers. It was previously known as Sutherlandia frutescens, according to the South African National Biodiversity Institute.

This plant is one of the most talked about in the ethnobotanical world because it has a strong reputation as a cure for cancer and now increasingly as an immune booster in the treatment of HIV/Aids. Research on its properties is ongoing.

“Lessertia frutescens has shown significant anticancer activity against several different cancer types in our research,” said NWU health sciences research professor Prof. Chrisna Gouws.

“An important consideration is that this plant has a long history of use, and is considered non-toxic and safe for use. Its anticancer activity comes without the significant side effects known to occur with most standard chemotherapies.

Prof. Chrisna Gouws said further studies will include animal model testing later this year. Photo: news.nwu.ac.za

“Chemotherapy can be very expensive and inaccessible in rural areas. A new plant-based treatment will be much more cost-effective and may be more accessible because it can be manufactured locally.”

Further studies will include animal model testing later this year to confirm safety and effectiveness before any potential clinical trials.

Beyond its direct impact on cancer cells, researchers are also exploring whether the plant may offer broader health benefits. Early findings suggest it could support the immune and digestive systems and may even have mood-enhancing properties.

“The project could also create economic opportunities. An increase in demand for the plant material will also create economic opportunities through farming,” said Gouws.

OFM News/Zenande Mpame

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