The fifth-seeded Garcia was beaten in a match lasting just under three hours by the Anna Blinkova of Russia with a 4-6, 6-3 and 7-5.

The 2017 champion, Jelena Ostapenko of Latvia, was also eliminated after losing 6-3, 1-6 and 6-2 to Peyton Stearns of the USA.

The Australian Open champion, Aryna Sabalenka, in her turn, beat Iryna Shymanovich 7-5 and 6-2 in an all-Belarusian affair.

Meanwhile, in the men's singles the 2015 champion, Stan Wawrinka, was beaten in a five-set thriller by Thanasi Kokkinakis of Australia.

The world number one Carlos Alcaraz and the 22-time Grand Slam champion, Novak Djokovic, are both through to the third round of the French Open at Roland Garros.

The top-seed Alcaraz was tested somewhat in beating Taro Daniel of Japan 6-1, 3-6, 6-1 and 6-2, while the third-seeded Djokovic in this turn beat Marton Fucsovics of Hungary 7-6, 6-0 and 6-3.

Meanwhile, on Thursday in the women's singles the top seed and defending champion, Iga Swiatek of Poland will face Claire Liu of the USA, while the Wimbledon champion, Elena Rybakina of Kazakhstan, will face Linda Noskova of the Czech Republic.