Zikalala sent his condolences to the families who lost their loved ones in the crash on the R56 road between Ixopo and Umzimkhulu.

Seven people including two children were killed.

"Let us be careful, let us understand that the roads are used not only by yourself who is driving your own car, understand that there are other people," Zikalala said.

"Let us be responsible, don't drive long-distance, if you drive for two hours, you must take a rest. Don't drive under the influence of alcohol."

Meanwhile, four fatalities have been reported on the freeway between Johannesburg and Durban so far.

In Mpumalanga, at least seven people have been killed over the last 24 hours in three separate crashes.

eNCA