She won for her performance in the movie "Everything Everywhere All at Once", which also won the award for Best Motion Picture. 

"This is proof that dreams … do come true," she said during her acceptance speech.

"And ladies, don’t let anybody tell you you’re ever past your prime," she added.

The movie is about a Chinese immigrant who gets unwillingly embroiled in an epic adventure where she must connect different versions of herself in the parallel universe to stop someone who intends to harm the multiverse.

Brendan Fraser won the Academy Award for best actor for his performance in “The Whale”.

Fraser, appearing visibly shocked and emotional upon accepting his trophy, thanked the film's director, Darren Aronofsky, for throwing him "a creative lifeline and hauling me aboard the good ship ‘The Whale’”. - LA Times.